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Inhibition of follicular advancement as well as the absence of a LH surge reduce ovulation.[47][forty eight] A secondary system of motion of all progestogen-that contains contraceptives is inhibition of sperm penetration by variations from the cervical mucus.[138] Inhibition of ovarian perform all through DMPA use leads to the endometrium to become skinny and atrophic. These improvements during the endometrium could, theoretically, reduce implantation. Nonetheless, for the reason that DMPA is highly helpful in inhibiting ovulation and sperm penetration, the potential of fertilization is negligible. No readily available information assist avoidance of implantation as being a mechanism of motion of DMPA.[138] MPA and relevant steroids at the progesterone receptor
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The chance/advantage of loss of bone mineral density (BMD) in Females of all ages and the influence on peak bone mass in adolescents need to be viewed as, combined with the lower in BMD that occurs during pregnancy and/or lactation, need to be assessed when working with Depo-Provera extended-term.
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